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Lignin nanoparticles, sourced from paper industry byproducts, demonstrate antioxidant properties and serve as sustainable platforms for therapeutic delivery in periodontal applications [43,44,45]

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Human clinical trial data are absent

Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss in rats by stimulating Nrf2 and nuclear factor-B, and activating insulin receptor substrate/PI3K/Akt axis

Generally, the composition is topically applied to the affected skin areas in a predetermined or as-needed regimen to bring about improvement, it generally being the case that gradual improvement is noted with each successive application