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In AD, the need for vitamins increases in order to compensate for their increased use.[39,47] In this study, low levels of vitamins B-2, C and A were found in patients with AD and MCI, in line with results from other authors.[10,11,39,47] It is not possible to infer causation in these associations or even potential reciprocal causation: that is, dementia as a factor that promotes poor nutritional intake, or, inversely, the process of dementia as a result of reduced nutritional intake in older adults.[39] One study limitation is that its cross-sectional design does not allow chronological ordering of events to be established, or, as a result, whether the nutritional indicators associated with MCI and AD can be determined to be the cause of the disease or merely a consequence of it

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A direct association between HHcy and IR is well demonstrated by Golbahar and colleagues using Sprague Dawley (SD) rats [71]