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Frontiers in Drug Studies Related to GBM Autophagy Autophagy and TMZ Chemotherapy Long-term doses of TMZ have been demonstrated to induce protective autophagy in GBM cells [174]

While glutathione is generally considered well-tolerated, some individuals may experience: Discomfort at the injection site Digestive changes such as bloating or cramping Headaches or temporary fatigue Rare allergic reactions Excessively high doses, especially when administered too frequently, may interfere with natural antioxidant regulation

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