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In dying neurons, lysosomal membranes become permeable or rupture outright, unleashing their contents into the cytosol and, ultimately, the extracellular milieu

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[DOI] [PubMed] [Google Scholar] 215.Vasilescu A., Sharpe E., Andreescu S

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Blocking autophagosome and autolysosome formation Once damaged mitochondria are recognized and tagged, a double-membrane structure known as the autophagosome, mediated by LC3 and other autophagy-related proteins, encapsulates them

Like other lipid A derivatives, MPLA can be enzymatically modified by host phosphatases and lipases, including dephosphorylation and deacylation, which alter lipid A bioactivity (4648)