It has been suggested that H 2 S is important in liver transplantation scenarios, as patients with liver failure cannot break down endogenous or dietary-derived sulfides.56 Vitamin B12 scavenges H 2 S in vitro to generate a reduced cobalamin derivative with soluble sulfites, which presumably can be cleared by the kidney if similar chemistry occurs in vivo .10,56 Animals exposed to H 2 S poisoning and treated with V-B12 show better survival rates.56 Vitamin B12 (3+) is the form that effectively binds H 2 S as opposed to its reduced or super-reduced forms.58 In vitro , cobalamin derivatives react with H 2 S to create persulfides, providing one mechanism for influencing H 2 S signalling.58 The US Department of Defense has expressed interest in using V-B12 as an antidote for H 2 S, a gas that can potentially be used as a weapon for chemical warfare
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