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The high unsaturated fatty acid content in the brain, the formation of free radical by-products as a result of high oxygen use, high lipid peroxidation and weak antioxidant defense system, the high reducing potential of various neurotransmitters, and the presence of redox-catalytic metals such as iron and copper can be counted among the reasons why the brain is more sensitive to oxidation

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The results showed that compared with the GGCT-knockdown alone group, neither of the above treatments alleviated intracellular ROS accumulation (Fig