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2.10 Molecular docking and molecular dynamics simulation analysis To investigate the potential role of gut microbiota-derived metabolites in regulating ferroptosis in RA, gut metabolites interacting with key genes were identified from the gutMGene database, and molecular docking and molecular dynamics simulation were employed to evaluate the stability of their interactions

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Astaxanthin, L-Glutathione, Vitamin C, Vitamin B2, Vitamin B3, Vitamin B6 and L-Cysteine

Therefore, approaches that quantify the anti-tumor immune response in solid tumors may not be directly applicable in MDS ( 3.3 Absolute monocyte counts and subsets in MDS The diagnostic criteria for MDS dictate that the absolute number of PB monocytes should not exceed 0.5x10^9/L, as surpassing this threshold would classify it as chronic myelomonocytic leukemia (CMML) ( A lower absolute monocyte count in PB and a higher lymphocyte-to-monocyte ratio (LMR) in PB are both linked to poor survival outcomes ( The general distribution of monocyte subsets in PB and BM is similar in MDS and healthy conditions ( Figure 3 )

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Michie, C