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These results suggested the potential of Syr to attenuate inflammatory response, myocardial fibrosis, and oxidative stress for the treatment of DCM, and its mechanism of action is related to TGF-/Smad2/3 and Keap1/Nrf2 signaling pathways

These complexities are further underscored by a recent report by Soriani et al., which suggests that CD38 can act as a decoy for extracellular cGAMP, a mediator of innate immunity