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Animal studies have not reported major toxicity, but the lack of comprehensive human data means risks are unknown467

Intervertebral disc disease often involves neuropathic pain components, which could benefit from drugs that influence NMDA receptor activity [24, 25]

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A methodical rotation plan that leaves the same patch unused for 3 to 4 weeks, combined with technique adjustments like injecting over 5 to 10 seconds and holding the needle for 5 seconds, substantially reduces repeated-site irritation

If someone tells you that as a hard fact, ask them for the study

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