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Peer review Peer review information Nature Communications thanks Thierry Galli, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

As an integral functioning part of these enzymes, selenium aids in the regeneration of glutathione and oxidized vitamin C

Vitamin C, a strong antioxidant that also reduces inflammation, is key for building collagen and repairing tissues

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IS-activated AHR is translocated to the nucleus and binds to xenobiotic response element sites, which inhibits NF-B activation and mitigation of the mutual inhibition of AHR and NF-B

doi: 10.1111/j.1464-5491.2006.01852.x 23 Guerrero-RomeroFTamez-PerezHGonzlez-GonzlezGSalinas-MartnezAMontes-VillarrealJTrevio-OrtizJet al