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To test this, we propose a minimal feasible, biomarker-enriched, single-arm trial for this patient subset, with co-primary endpoints of safety and objective response rate (ORR)

While glutathione is generally considered safe when taken in appropriate doses, excessive supplementation can result in side effects like gastrointestinal discomfort, nausea, and allergic reactions

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Nonetheless, it is feasible that in some conditions other tissues such the heart, lungs or white blood cells may contribute significantly to the total body generation of ROS (313)

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Over 80 are FDA-approved, and more than 170 are in active clinical trials right now