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Homozygous 677T mutations have been associated with increased incidence of bilateral breast carcinoma, endometrial carcinoma and colorectal carcinomas (8)

Vavouri, T., Semple, J

Watterlot L, Rochat T, Sokol H, Cherbuy C, Bouloufa I, Lefvre F, et al

The cisplatin-treated cells were also shrunken, with their membranes rounded up, and they lost contact with either neighboring cells or the culture plate

These fibres alignment mimicked the ECM environment naturally by giving the cells a physical cue to move along

We recently showed that HIF1 also induces the expression of NDUFA412, which has a HIF-binding site in its proximal promoter (Tello et al., 2011)