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Physical Activity and Recovery While regular exercise is vital for health, intense physical training creates temporary oxidative stress

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As the efficacy of single-agent metabolic inhibitors is often limited by metabolic plasticity, developing rational combination therapies based on the coordinated targeting of oncogenic signaling and its downstream metabolic dependencies holds promise for systematically overcoming resistance and achieving more durable therapeutic benefits in tumors with specific genetic backgrounds

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Consistent with the NAPstar response, we observed almost no HyPer7 response in glucose-fed cells, except at the highest H 2 O 2 concentration, suggesting that HeLa cells can very efficiently remove H 2 O 2