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PIP-ELISA collagen output at matched late passages (passage 18 vs passage 18) is preserved in Epitalon-treated HDFs relative to vehicle-treated cells that have accumulated more telomere damage at the same passage demonstrating that Epitalons replicative lifespan extension translates to functional preservation

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The UBD gene can produce a ubiquitin-like protein that modifies APOL-G1 and APOL-G2 proteins to promote their lysosome breakdown and reduce their cytotoxicity[118]

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10.1038/s41586-023-06009-4 Nature 94 LinF