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Cardiac-resident macrophages and the endothelium detect these danger signals, initiating the recruitment of blood neutrophil to clear cellular debris from the tissue environment 109

Additionally, MG53 protein activates the Nrf2 pathway in senescent human umbilical cord mesenchymal stem cells (hUC-MSCs), significantly enhancing their capacity to clear A deposits and suppress neuronal ferroptosis, thereby advancing sulforaphane-cell combination therapy (250)