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Oxidative Stress and Damage: A Vital Pathogenic Mechanism of CIPN It is well established that the production of reactive oxygen species (ROS) by antineoplastic agents induces apoptosis in cancer cells [14]

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It effectively separates complete succinylcarnitine and methylmalonylcarnitine from their isomers, allowing for more accurate quantification of these metabolites and aiding in distinguishing typical methylmalonic acidemia from succinyl-CoA synthetase-related defects

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Furthermore, supplementary backward citation tracking was performed manually by screening the reference lists of retrieved seminal articles and previous systematic reviews to identify any additional pertinent literature that may have eluded the primary database search