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TLR4 signaling promotes the production of reactive oxygen species (ROS) via NADPH oxidase (NOX) enzymes and mitochondrial dysfunction, and the resulting oxidative stress causes further cellular damage, releasing more DAMPs that re-activate TLR4

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Citations Citations to this article as recorded by Entinostat suppresses hepatocellular carcinoma metastasis by upregulating AZGP1 through histone acetylation Weiguo Cai, Xinru Pei, Xiaodie Ye, Yan Zhai, Na Wu, Ziyi Wang, Wei Lu Biochemical Pharmacology .2026