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Levels naturally decline with age, which has fuelled interest in whether supplementation can reverse age-related tissue changes

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Systemic injection of human ExerVs during hindlimb unloading enhances recovery of Type I fibers during reloading Based on the results above, we speculated that ExerV treatment during disuse may alter the ECM environment in a beneficial manner that may promote fiber growth during reload 33

Thus, Mn-based porphyrins may act as prooxidants in an environment rich in electrons, such as mitochondria, where electron transfer from the biological environment to metal-(Mn)-complexes may occur