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211 YangHWangJZhangXZhangYQinZ-LWangHet al

At the same time, Caspase-1 processes Gasdermin D (GSDMD), thereby allowing the N-terminal GSDMD domain to form pores in the plasma membrane, which contribute to the egress of IL-1 and also cause the lytic form of cell death known as pyroptosis 10,11,12,13