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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

The circulating level of IGF1 coupled with IGFBPs has been correlated with the risk of developing various cancers, including breast, lung, colon, and prostate cancers through human epidemiological studies (Hankinson et al., 1998

In summary, there are many residues that have been identified that could be mutated to prevent the secretion and uptake of Tat and its ensuing toxicities

Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation

Thus, different studies have also suggested the adverse impact of COVID-19 on male reproductive functions, mainly emphasizing on high expressions of angiotensin-converting enzyme 2 (ACE2) in the testes that allows the viral entry into the cells

3 Institute of Biomedical Sciences, University of So Paulo, So Paulo, Brazil