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Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors : First Italian Clinical Trial

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In Embodiment 3 of this disclosure are compounds of Formula I, or any one of Embodiments 1-2, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 1 is In Embodiment 4 of this disclosure are compounds of Formula I, or any one of Embodiments 1-3 or a pharmaceutically acceptable salt of any of the foregoing, wherein R 1 is phenyl substituted with a substituent selected from: hydroxy, halogen CN, C 1-3 alkyl, C 1-3 alkyl-CN, OC 1-3 alkyl-CN, C 1-3 haloalkyl, C 3-6 cycloalkyl, OC 1-3 alkyl, OC 1-3 haloalkyl, O-cyclopropyl, 5 membered heteroaryl containing 2 nitrogen atoms, S(O) 2 C 1-3 alkyl, S(O) 2 NHC 1-3 alkyl, or C 1-3 alkylNH 2 , and wherein the cycloalkyl moiety is optionally further substituted with F, CH 3 , CF 3 , CN, or OH

Het ondersteunt ook de werking van andere antioxidanten, zoals vitamine C en E, en helpt het immuunsysteem te versterken

High-density lipoprotein-associated apolipoprotein M limits endothelial inflammation by delivering sphingosine-1-phosphate to the sphingosine-1-phosphate receptor 1

The surface of the nanoparticle could be coated with a protective layer for stability issues in the body fluids and be tagged by different ligands on the outside to attach preferentially to receptors of the cancer cells (Zarei et al., 2021)