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doi: 10.1002/jbmr.59 67

Recent studies have also reported that POR and CYB5R1 can transfer electrons from NAD(P)H to oxygen to generate the H 2 O 2 , which subsequently reacts with iron to generate hydroxyl radicals for further promoting the peroxidation of PUFA of PLs-PMs, thereby disrupting membrane integrity and leading to ferroptosis [40, 41]

G.GratadouxJ

Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons

and how this encounter is spatially and temporally controlled

A docking grid was defined around the active sites of the proteins via 29 and molecular docking was performed using PyRx 30