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Description

Despite the extensive information available on nanomaterial formulation, characterization, ocular administration, and targeting, addressing the toxicity and safety of these materials remains an urgent requirement

Nano Res 2019, 12, 855861

Modulation of sensitivity to phospholipid oxidation and ferroptosis by tumor suppressors and oncogenes is mediated by changed expression or activities of proteins that exert different functions in lipid peroxidation including those regulating iron handling (transferrin receptor, NCOA4), enzymes synthesizing peroxidation-prone PUFA-phospholipids (ACSL4), antioxidant enzymes (GPX4) and proteins involved in production of antioxidant proteins (NRF2) or small antioxidant molecules (SLC7A11, FSP1)