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Phase II Detoxification in the Liver Glutathione transferases (GST) conjugate GSH directly to endogenous and exogenous electrophilic compounds, including xenobiotics, carcinogens, and heavy metals

Furthermore, a recent study reported a small molecule, KDS12025, which can increase the activity of hemoglobin pseudoperoxidase by 100fold even at low hemoglobin levels

For those without an absorption problem, research suggests that high-dose oral B12 supplements can be as effective as injections in raising and maintaining B12 levels

Moreover, as shown for the GPx isoenzymes proteins or enzymes might behave differently than the general consensus predicts, such as differing subcellular localizations or enzymatic activities

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In such cases, supplementation with sublingual B12 may be recommended as a means of restoring B12 levels