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Keywords: folate, gene variants, MTHFR 1

March 18 Product: Orchard Therapeutics Lenmeldy Indication: Metachromatic leukodystrophy Monday, the FDA gave a glimmer of hope to families of children with metachromatic leukodystrophy (MLD), a rare genetic disease affecting the brain and nervous system, with the approval of Orchard Therapeutics Lenmeldy

Bae S, Kim SR, Kim M-N, Shim WJ, Park S-M

In mouse experiments, Klevay and Viestenz (116) observed that copper-deficient rats exhibited a range of electrocardiographic abnormalities, including ST-segment depression spanning one-third to one-half of the RR interval, bundle-branch block with R-wave heights and widths three times the normal values, Q-waves, and second- and third-degree heart block

The Bridge operates outside Part D the $50 copay does not count toward the $2,100 OOP cap, TrOOP, or Extra Help

Nature 448 : 553560