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Description

However, very large VLDL particles cannot be secreted if their diameter exceeds that of the sinusoidal endothelial pores, and this limitation may ultimately result in lipid retention and NAFLD [120]

What is bioaccumulation

In vitro cytotoxicity and cell apoptosis assays confirmed the safety of DBP, while radical scavenging assays and measurements of intracellular reactive oxygen species (ROS) demonstrated its strong antioxidant capacity

Although thiamine deficiency is rare in developed countries, it can lead to severe neurological disorders, emphasizing the importance of adequate thiamine intake for optimal health and as treatment when administered promptly (42)