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Overall, mAbs have demonstrated encouraging clinical benefits when added to platinum regimens in various studies, albeit with some variability in results

In most healthy people: yes

Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues

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Nevertheless, we cannot exclude that the observed effect was driven by the nonsignificant group difference in CPZ equivalents

Therefore, not only antioxidative activity but also conjugation to platinum might be involved in the amelioration of oxaliplatin-related neurotoxicity