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STAT3 is responsible for mediating cellular responses to growth factors, interleukins, etc., and plays a part in cellular processes like apoptosis 42 , while also acting as a regulator of inflammatory responses 43

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Proteomics may also help in identifying one missing step in the gamma-glutamyl cycle, i.e., the cysteinyl-glycine dipeptidase, whose occurrence is inferred but not demonstrated yet

It is reported that patients with acute myocardial infarction has a three times higher prevalence of depression compared to the general population, while patients with New York Heart Association (NYHA) class IV HF exhibit a four-fold higher incidence of depression than those with NYHA class I HF [88]

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Thus vitamin C supplementation may be a potential therapeutic agent to improve symptoms of PD