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In addition, the median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (18.0 d), dermatitis/rash (24.0 d), and endocrine events (57.0 d) for participants who received STRIDE in our study differed when compared with the phase I/II multicohort CheckMate040 study (NCT01658878), which assessed multiple doses of nivolumab plus ipilimumab and reported an approximate median time to onset of hepatitis (39.256.7 d), diarrhea/colitis (58.8172.2 d), rash events (14.7135.8 d), and endocrine events (hyperthyroid events, hypophysitis, and hypothyroid events

2011;6 doi: 10.1371/journal.pone.0026891

The method, in generating a non-stochastic range of single amino acid substitutions, can comprise performing amplification reactions on the nucleic acid of step (a) using the set of oligonucleotides to generate a set of variant nucleic acids encoding nineteen amino acid substitution variants at a single amino acid residue of the antibody

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This transcriptional regulatory mechanism represents an important pathway for cells to enhance cystine uptake, promote glutathione synthesis, and thus respond to oxidative damage and maintain cellular redox homeostasis