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Either decreasing ACSL4 by blocking serine/arginine splicing factor 1 (SRSF1) with lncRNA TUG1 carried by urine-derived stem cells (USCs)-derived exosomes (USC-Exo), or inhibiting the activation of the c-Jun NH2-terminal kinases (JNK) pathway by inositol requiring enzyme 1 (IRE1), a proximal ER stress sensor, can inhibit the H/R-induced ferroptosis of HK-2 cells [153,154]