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Now we know that the British National Formulary (BNF), that little booklet that is produced twice a year by the Royal Pharmaceutical Society and the Royal Society of Medicine which acts as a reference for doctors to consult in order to treat patients correctly, used to recommend a 1mg injection of Hydroxocobalamin every month when the injection was introduced at the start of the 1960s

Development of auto-antibodies Some cobalamin preparations in rare cases can stimulate an allergenic response where there is development of antibodies to the cobalmin injected