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292 In HD, the GABAergic neurons in the striatum and cortex are the most affected, contributing to clinical hallmarks such as chorea, cognitive impairment and nonmotor symptoms

10.1101/gad.1252404 Genes Dev

SIRS are nonspecific and may or may not be related to infections by pathogens and is defined by the following clinical criteria: fever greater than 38 C or less than 36 C

These challenges underscore the necessity of integrating disease-specific modeling with pharmacological optimization and targeted delivery strategies, thereby transforming experimental ferroptosis models into translational platforms for musculoskeletal therapy development (Table II)