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Furthermore, icariin exhibits dual anti-cancer mechanisms by decreasing polymorphonuclear-MDSCs and inhibiting macrophage differentiation from the M1 to M2 phenotype in pancreatic cancer (Panc02) cells [698, 704]

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GLV production can influence the phytohormonal network, especially JA, ET and SA that shape the core of plant direct defense organization, and in some cases, unexpectedly, leading to higher susceptibility to pathogens in spite of the antimicrobial activity of GLVs in vitro