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In another embodiment, the total amount of all Active Agents meant to influence the skin of the user, combined per dose (single use or application of a toothpaste of the invention) ranges from about 0.1 mg to about 10 g, in a further embodiment from about 1 mg to about 1 g and in still a further embodiment, the total amount of such actives per dose should range from about 1 mg to about 500 mg and in yet another embodiment, from about 1 mg to about 500 mg Alternatively, the amount of total Active Agents supporting the health, well- being and/or appearance of a users skin through the application to the oral cavity of a single dose of a toothpaste in accordance with the present invention, expressed in weight percent (wt %) can range from about 0.1 to about 20 wt %, and in another embodiment, from about 0.1 to about 10 wt % and in still a further embodiment, from about 0.1 to about 5 wt % based on the total weight of each dose of toothpaste which is intended to be applied

The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model