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Hum S, Koski KG, Hofet LJ: Varied protein intake alters glutathione metabolism in rats

Zn-deficient wild-type and mutant human SOD1 have been implicated in the disease familial amyotrophic lateral sclerosis (FALS), also known as Lou Gehrigs disease which affects the nerve cells in the spinal cord and the brain.29, 30 Recently, Dayal and colleagues informed that deficiency of superoxide dismutase promoted cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.31 SOD enzyme deficiency is common

Zheng H-L, Zhang H-Y, Zhu C-L, Li H-Y, Cui S, Jin J, et al

10.1038/s41416-021-01566-9 Br J Cancer

While initially activated by their pro-inflammatory microenvironment, at a certain stage, fibroblasts acquire an epigenetically imprinted aggressive phenotype switching from responders to drivers, and hence switching the disease from acute to chronic ( in vivo

In addition to causing constant cellular injury, chronic inflammation creates a microenvironment very similar to that of cancers, which favors the establishment, infiltration, and growth of neoplasms (102)