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A., Abdulhadi, A., Alsayyad, A

The relationship between dose and response follows a curve that plateaus, not a straight line that keeps climbing

However, genetic studies in yeast lacking both sam1/sam2 (MAT1/MAT2 orthologs) demonstrated that SeAM synthesis can occur but is highly toxic, which may explain the toxicity previously associated with its precursor SeMet [67]