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People treated with CagriSema lost 20.4% of their body weight over 68 weeks, versus 11.5% with cagrilintide 2.4 mg alone, 14.9% with semaglutide 2.4 mg alone, and 3.0% with placebo

Similar results were observed in IEC6 and Caco-2 cells treated with metformin, demonstrating consistent ME1 and TXNRD1 upregulation (Supplementary Fig