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Many people assume that if a capsule contains 500mg of glutathione, their body is getting 500mg

These processes are controlled by SAM and SAH, which depend on vitamins B6, B9, and B12

Enhanced nuclear translocation of TFEB boosts the expression of lysosomal proteins and superoxide dismutase (SOD), ultimately diminishing ROS levels and suppressing ferroptosis, thus exerting a protective effect (254)

An example of when lowering GCLM/GCLC causes decreased GSH is the expression of the HIV-Tat protein, which suppresses GCLM expression (Choi et al., 2000)

Alternatively, GSH is efficiently synthesized by utilizing intracellular cysteine (L-cysteine), glycine and glutamate, with the assistance of specific enzymes (37,38)

Table 1 Annotations features for glutathione transferase of Spirometra mansoni