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When the amount of tyrosinase is reduced, the melanin formation process is also prevented, leading to brighter skin and less darkening

Del Priore G, Gudipudi DK, Montemarano N, Restivo AM, Malanowska-Stega J

Tezuka, T

Detailed mechanism [edit] Two aspartate amino acid residues (below left) are interacting with two adjacent water molecules (w6 and w8) in the Mn 2+ isocitrate porcine IDH complex to deprotonate the alcohol off the alpha-carbon atom