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Responses to immune-checkpoint inhibitors (ICIs) in patients with NSCLC correlate with a high TMB as well as with a high number of transversions as part of a smoking-related mutational signature 135

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These injections are ideal for individuals who are deficient in B12 or have trouble absorbing it through diet alone

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Additionally, the presence of a mechanism in a petri dish or mouse model does not guarantee clinical relevance in humans

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