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10.1056/NEJMoa2021436 109 RiazA.RasulA.HussainG.ZahoorM

After two years of treatment, an increase in bone mineral density and a decrease in urine calcium concentration was seen with both medication regimens, but the group treated with alendronate plus hydrochlorothiazide had more improvement than the group treated with alendronate alone (Arrabal-Polo, Arias-Santiago 2013)

Antioxidants and cancer therapy: furthering the debate

Consistently, in relapsed AML/MDS after allo-HCT, high frequencies of CTLA-4/PD-1 and multi-ICMco-expressing T cells and blasts are detectable in uncultured blood and associate with impaired antileukemic activity and poor response to salvage therapy (54)

Compared to age-matched controls, PD patients exhibited significantly elevated levels of proinflammatory cytokines such as IL-1B, IL-6, and TNF in CSF and blood (58)