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GSH may promote cisplatin detoxification, once it can bind covalently to intracellular cisplatin, preventing it from reacting with DNA, its therapeutic target

Bobylev I, Elter T, Schneider C, Wunderlich G, Zimmer P, Streckmann F, et al

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Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1-induced metabolic reprograming

Compared to the placebo group, those who received the silymarin saw a "significant decrease" in their levels of key diabetic markers hemoglobin A1C, fasting blood sugar, total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides.17 The second is a recent review published in the Annals of Hepatology in 2021, much of which relates to silymarin's effect on insulin resistance,18 a prominent marker for type 2 diabetes.19 Two of the studies referenced in the review were animal studies that administered 26.25-100mg/kg of silybin to rat subjects (equivalent to around 366-1,395mg for an 86kg, or 190lb, human) across 6-12 weeks