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Marettova E, Maretta M, Legath J

Lopes, NMD, Lens, HHM, da Silva Brito, WA, Bianchi, JK, Marinello, PC, Cecchini, R., Cecchini, AL

Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

Following alkylation by add IAM (Iodoacetamide) for 40 min at room temperature under dark conditions

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration