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Although experimental structural information on DIDO SPOC is lacking, AlphaFold2 structure prediction 26,27 shows that the conserved residues cluster in patches on the domain surface similar to PHF3 SPOC (Fig

For example, acid-responsive NCT-503@Cu-HMPB nanoparticles enable tumor microenvironment-specific drug release, effectively inhibiting tumor growth while reducing systemic toxicity (125)