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While cytosolic and blood GSH and Cys biochemical species all experience depletion, the model predicts that a single exposure to doxorubicin only results in a minimal perturbation of the antioxidant defence system

Specifically, in-house donors exhibited lower NAD + , NADH and NADP + levels (on average 3.2, 0.47 and 1.6 uM lower, respectively) but higher NADPH levels (on average 0.88 uM) compared to biobank samples (Supplementary Figure 2a)