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The direct and indirect effects of ALC on energy metabolism, NO, and consequently serotonin modulation are probable neuroprotective mechanisms involved in alleviating depressive-like behaviors in the cuprizone mouse model of MS

Ratzka P., Klinikum Augsburg, Department of Neurology

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it can be present from the early stages of the disease and affects up to 70% of patients

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Finally, we outline a prospective research agenda, encompassing pharmacokinetic/pharmacodynamic (PK/PD)-guided precision dosing, exploring non-antibiotic adjuvants, and developing more predictive preclinical models to unlock the full potential of fosfomycin-based combinations against MDR infections