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FIGURE 6 3.5 Other mechanisms In addition to bile stasis, interference with liver regeneration, oxidative stress responses with mitochondrial dysfunction, and endoplasmic reticulum stress responses, the hepatotoxicity of PSO involves other related pathways such as drug metabolism and amino acid metabolism

Factors secreted by adipocytes that enhance or suppress inflammation 2

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Injectable anti-aging protocol: Dose: 1-2mg daily Frequency: 5 days on, 2 days off OR daily for 30 days Cycle: 30 days on, 14 days off Duration: Minimum 2-3 cycles for substantial results Topical anti-aging protocol: Concentration: 2-3% serum or cream Application: Twice daily (morning and evening) Duration: 12+ weeks continuous use Combine with: Sunscreen (always), retinoids (evening, separate application) Combination approach: Maximum anti-aging results come from combining injectable and topical

- Th tch : 50ml

For wellness purposes, our healthcare providers may suggest injections every three to four weeks