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Notably, S340A/S788A mutant failed to inhibit cell death, RIPK1 and caspases activation induced by TNF alone or TNF/CHX in HK2-KO MEFs, but D209A/D657A mutant protect HK2-KO MEFs from TNF alone or TNF/CHX treatment (Supplementary Fig

Biases towards subject inclusion may have existed, given the lack of treatment alternatives

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