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doi:10.1097/AOG.0000000000003514 Clayton AH, Althof SE, Kingsberg S, et al

Oral mucosal melanin hyperpigmentation associated with syndromes and systemic diseases Oral mucosal melanin hyperpigmentation is often observed in the systemic conditions such as Peutz-Jegher syndrome, McCune-Albright syndrome, Laugier-Hunziker syndrome, Addison disease, and neurofibromatosis

Grichnik JM

Autoradiograms were then generated by exposing the sections to Biomax MR film, and the resulting digital images were quantitatively analyzed using Image J software, with five brains analyzed per group [1]

Indeed, it has been suggested that certain cytokines that are upregulated during HIV infection have the capacity to induce the production of -MSH by oral melanocytes and keratinocytes and to mediate the upregulation of expression of MC1R by melanocytes, resulting in increased melanin production