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For analysis of spontaneous locomotion data, a two-way ANOVA was performed

Direct cellular interactions and growth factor modulation: Peptides can interact directly with cell membranes, DNA or proteins to disrupt pathological processes or to deliver therapeutic cargo inside cells

Hepatocytes that highly express SHH appear colocalized within fibrotic areas in livers of NASH patients (208), and are proximal to areas of hepatic progenitor cells (209), consistent with the observation that SHH signaling promotes and maintains a de-differentiated liver cell state (210)

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Clinicians should evaluate patient compliance with prescribed regimens, assess for misuse or diversion in the outpatient setting, and remain informed of changing guidelines related to safe opioid prescribing practices